Mutual protection of SEBHs in the two subunits of mitochondrial respiratory chain complex III. (a) Ribbon representation of mitochondrial respiratory chain complex III (PDB.1KB9). The high structure vulnerability of subunit 1 (red; compare Figure 2) renders it highly needy for interaction with other subunits of the complex to maintain its structural integrity. (b) SEBH pattern for subunit 1 (red) and subunit 2 (blue). The interacting pair is characterized by a very high expression correlation η = 3.61. The yellow square highlights the part of the interface shown in detail in (c). (c) Illustration of mutual protections of SEBHs in the two subunits along part of their interface. One side-chain bond (between α and β carbons) is displayed. The thin blue lines, which connect β-carbons in one protein with centers of hydrogen bonds in the other protein, represent mutual protections of hydrogen bonds across the protein-association interface. Thus, a thin line is shown whenever the side chain of one protein is contributing with nonpolar groups to the microenvironment of a preformed hydrogen bond in its binding partner.
Chen et al. Genome Biology 2008 9:R107 doi:10.1186/gb-2008-9-7-r107