Table 1

Common genes significantly decreased in glaucomatous ONH astrocytes compared to their normal counterparts

AAG-AA (U133Av2)

CAG-CA (U95Av2)



Symbol

Description

CL

FC

p-value

FC

p-value


AMIGO2

Adhesion molecule with Ig-like domain 2

12q13.11

-1.52

0.0498

-2.01

0.0011

BMP1

Bone morphogenetic protein 1

8p21

-1.92

0.0005

-2.08

0.0001

CD97

CD97 molecule

19p13

-1.65

0.0015

-1.36

0.0008

CRIP2

Cysteine-rich protein 2

14q32.3

-2.58

0

-1.44

0.0034

DGKA

Diacylglycerol kinase, alpha 80 kDa

12q13.3

-1.54

0.0034

-1.28

0.0001

DMPK

Dystrophia myotonica-protein kinase

19q13.3

-2.45

0

-1.62

0.0021

EFHD1

EF-hand domain family, member D1

2q37.1

-4

0

-2.01

0.0011

GPC1

glypican 1

2q35-q37

-1.61

0.0032

-1.31

0.0026

MGLL

Monoglyceride lipase

3q21.3

-1.52

0.0083

-1.75

0.0005

MICAL2

Microtubule associated monoxygenase, calponin and LIM domain containing 2

11p15.3

-1.62

0.0186

-2.02

0.0013

NPAL3

NIPA-like domain containing 3

1p36.12-p35.1

-1.54

0.0034

-1.51

0.0079

PDGFA

Platelet-derived growth factor alpha polypeptide

7p22

-1.65

0.0076

-2.21

0.0004

SLC12A2

Solute carrier family 12, member 2

5q23.3

-1.61

0.0032

-1.51

0.0001

SLC12A4

Solute carrier family 12, member 4

16q22.1

-2.42

0.0007

-1.19

0.0046

SMTN

Smoothelin

22q12.2

-1.79

0.0162

-1.99

0.001

WWP2

WW domain containing E3 ubiquitin protein ligase 2

16q22.1

-1.87

0.0006

-1.39

0.0029


CL, chromosome location; FC, fold change.

Lukas et al. Genome Biology 2008 9:R111   doi:10.1186/gb-2008-9-7-r111

Open Data