Table 2

Differentially expressed genes in glaucomatous astrocytes*

Gene

Description

FC

p-value

CL


Genes associated with myosin regulation

CALM1

Calmodulin 1

2.23

0.00121

14q24-q31

MYH10

Myosin, heavy chain 2

1.64

0.00588

17p13.1

MYLK

Myosin, light polypeptide kinase

2.89

0.000133

3q21

PIK3R1

Phosphoinositide-3-kinase, subunit (p85-alpha)

1.62

0.00201

5q13.1

MYPT1

Protein phosphatase 1, regulator subunit 12A (PPP1R12A)

1.51

0.000775

12q15-q21

RAC2

Ras-related 2 (Rho family, Rac2)

2.34

0.001059

22q13.1

RPS6KA3

Ribosomal protein S6 kinase, 90 kDa, polypeptide 3

1.5

0.000061

Xp22.2-p22.1

Genes associated with actin regulation

ARHGEF7

Rho guanine nucleotide exchange factor (GEF) 7

1.71

0.000064

13q34

NCK1

NCK adaptor protein 1

1.64

0.000015

3q21

PDLIM1

PDZ and LIM domain 1 (elfin, CLP36)

1.61

0.00106

10q22-q26.3

PIK3R1

Phosphoinositide-3-kinase, regulatory subunit 1

1.61

0.002012

5q13.1

PLEC1

Plectin 1, intermediate filament binding protein

-1.82

0.00199

8q24

PTPN11

Protein tyrosine phosphatase, non-receptor type 11

-1.9

0.000005

12q24

RAC2

Ras-related 2 (Rho family, Rac2)

2.34

0.001059

22q13.1

SMAD3

SMAD, mothers against DPP homolog 3

1.9

0.000488

15q22.33

TGFBR1

Transforming growth factor, beta receptor I

-1.57

0.000038

9q22

TGFBR2

Transforming growth factor, beta receptor II

2.11

0.007253

3p22

Genes associated with protein trafficking

APPBP1

Amyloid beta precursor protein binding protein 1

1.62

0.001688

16q22

CCL5

Chemokine (C-C motif) ligand 5

-1.74

0.002283

17q11.2-q12

CDH2

Cadherin 2, type 1, N-cadherin (neuronal)

1.55

0.003173

18q11.2

COL4A4

Collagen, type IV, alpha 4

1.59

0.002335

2q35-q37

CTNNB1

Catenin (cadherin-associated protein), beta 1, 88 kDa

2.14

0.005445

3p21

CTNND1

Catenin (cadherin-associated protein), delta 1

1.68

0.000025

11q11

GOLGA1

Golgi autoantigen, golgin subfamily a, 1

1.51

0.00002

9q33.3

GOLGA2

Golgi autoantigen, golgin subfamily a, 2

1.77

0.000002

9q34.11

GOLGA3

Golgi autoantigen, golgin subfamily a, 3

1.97

0.000128

12q24.33

HAPLN1

Hyaluronan and proteoglycan link protein 1

8.04

0.001193

5q14.3

PRSS3

Protease, serine, 3 (mesotrypsin)

2.53

0.005135

9p11.2

RAB1A

RAB1A, member RAS oncogene family

1.51

0.000274

2p14

RAB4A

RAB4A, member RAS oncogene family

1.52

0.00035

1q42-q43

RAB5B

RAB5B, member RAS oncogene family

1.5

0.0081

12q13

RAB9A

RAB9A, member RAS oncogene family

1.64

0.000256

Xp22.2

RAB9P40

RAB9 effector protein with kelch motifs

1.84

0.000002

9q33.3

RABGGTB

Rab geranylgeranyltransferase, beta subunit

1.76

0.000375

1p31

TGM2

Transglutaminase 2

2.75

0.008289

20q12

VCAN

Versican (chondroitin sulfate proteoglycan 2, CSPG2)

2.94

0.000265

5q14.3


*Genes differentially expressed in AAG compared to CAG (Additional data file 7) except where noted. From Additional data file 5. From qRT-PCR data (Figure 3b). FC, fold change; CL, chromosome location.

Lukas et al. Genome Biology 2008 9:R111   doi:10.1186/gb-2008-9-7-r111

Open Data