Table 3

Common genes significantly increased in glaucomatous ONH astrocytes compared to their normal counterparts

AAG-AA (U133Av2)

CAG-CA (U95Av2)

Symbol

Description

CL

FC

p-value

FC

p-value

ABCA8

ATP-binding cassette, sub-family A, member 8

17q24

2.34

0.0291

2.53

9.43E-05

C5orf30

Chromosome 5 open reading frame 30

5q21.1

1.57

0.0028

1.48

0.0042

CASK

Calcium/calmodulin-dependent serine protein kinase

Xp11.4

1.99

0.0064

1.31

0.002

CASP4

Caspase 4, apoptosis-related cysteine peptidase

11q22.2-q22.3

1.59

0.0007

1.9

0.0026

GSTA4

Glutathione S-transferase A4

6p12.1

1.25

0.005

1.85

5.21E-05

GULP1

GULP, engulfment adaptor PTB domain containing 1

2q32.3-q33

1.89

0.0023

1.38

0.0075

HEPH

Hephaestin

Xq11-q12

4.15

0.0021

1.88

0.0021

HOXB2

Homeobox B2

17q21-q22

1.59

0.0133

1.86

0.0014

KCNK2

Potassium channel, subfamily K, member 2

1q41

1.55

0.0489

1.52

0.0024

KIAA1199

KIAA1199

15q24

1.68

0.0152

1.94

0.0026

LMO4

LIM domain only 4

1p22.3

1.7

0.0034

1.83

0.0052

MYH10

Myosin, heavy polypeptide 10, non-muscle

17p13

1.64

0.0012

1.57

0.0017

PYGL

Phosphorylase, glycogen; liver

14q21-q22

1.47

0.0141

2.2

0.0025

RBP1

Retinol binding protein 1, cellular

3q23

2.2

0.0007

2.32

0.00073

SERPING1

Serpin peptidase inhibitor, clade G, member 1

11q12-q13.1

2.3

0.0064

1.86

0.0014

SH3BP5

SH3-domain binding protein 5

3p24.3

1.65

0.0407

2.74

4.87E-05

SLIT2

Slit homolog 2

4p15.2

1.6

0.0077

1.42

0.0027

TINP1

TGF beta-inducible nuclear protein 1

5q13.3

1.53

7.93E-05

1.36

0.0055

CL, chromosome location; FC, fold change.

Lukas et al. Genome Biology 2008 9:R111   doi:10.1186/gb-2008-9-7-r111