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Open Access Research

The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells

Li Zhou12, Hongjie Wang1, Xing Zhong1, Yulan Jin1, Qing-Sheng Mi12, Ashok Sharma1, Richard A McIndoe12, Nikhil Garge1, Robert Podolsky13 and Jin-Xiong She12*

Author Affiliations

1 Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 15th Street, Augusta, GA 30912, USA

2 Department of Pathology, Medical College of Georgia, 15th Street, Augusta, GA 30912, USA

3 Department of Medicine, Medical College of Georgia, 15th Street, Augusta, GA 30912, USA

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Genome Biology 2008, 9:R119  doi:10.1186/gb-2008-9-7-r119

Published: 29 July 2008

Additional files

Additional data file 1:

Figure S1: anti-TGF-β cannot block the suppression function of CD8+ NKT-like cells. Figure S2: IFN-γ restores the viability of in vitro cultured CD8+ NKT-like cells from IFN-γ-/- mouse.

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Open Data