Table 5 |
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|
Gene expression levels for genes encoding critical surface markers |
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|
Symbol |
Function |
NKT/nCD8 |
CD4/nCD8 |
aCD8/nCD8 |
NKT/nCD8 (q) |
CD4/nCD8 (q) |
aCD8/nCD8 (q) |
|
|
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|
Ifitm1 |
Suppression |
89.9 |
7.1 |
1.5 |
2.8E-07 |
2.2E-03 |
2.4E-01 |
|
Lilrb4 (ILT3) |
Suppression |
50.3 |
43.8 |
7.6 |
3.6E-04 |
4.0E-05 |
5.6E-03 |
|
Ifitm2 |
Suppression |
45.6 |
11.4 |
1.6 |
6.0E-07 |
2.1E-03 |
2.8E-01 |
|
Havcr2 (Tim3) |
Suppression |
36.5 |
10.4 |
0.7 |
1.6E-04 |
2.0E-03 |
2.4E-01 |
|
Tnfrsf9 (4-1BB) |
Suppression |
28.2 |
12.5 |
12.8 |
2.4E-04 |
3.2E-03 |
1.1E-02 |
|
Tnfsf6 (FASL) |
Suppression |
24.4 |
4.3 |
3.2 |
1.2E-05 |
6.1E-02 |
4.5E-02 |
|
Ifitm3 |
Suppression |
24.3 |
15.6 |
0.8 |
2.5E-05 |
1.4E-03 |
6.6E-01 |
|
Ctla4 |
Suppression |
5.3 |
18.7 |
21.5 |
2.8E-03 |
4.8E-03 |
2.7E-03 |
|
Tnfrsf18 (GITR) |
Suppression |
4.8 |
11.1 |
4.4 |
2.7E-03 |
4.3E-05 |
1.7E-02 |
|
Pdcd1lg2 |
Suppression |
4.6 |
7.3 |
3.3 |
5.4E-04 |
2.5E-04 |
3.0E-02 |
|
Icos |
Suppression |
4.6 |
4.0 |
3.6 |
2.8E-03 |
3.5E-03 |
3.2E-02 |
|
Tnfsf11 (RANKL) |
Suppression |
3.9 |
8.1 |
27.0 |
7.6E-03 |
2.4E-03 |
3.4E-03 |
|
Tnfsf10 (TRAIL) |
Suppression |
3.1 |
3.2 |
1.8 |
2.7E-03 |
9.5E-03 |
6.6E-02 |
|
Tnfrsf4 (OX40) |
Suppression |
3.0 |
23.8 |
11.3 |
1.6E-02 |
7.6E-06 |
5.7E-03 |
|
P2ry14 (Gpr105) |
Receptor |
65.4 |
6.9 |
1.1 |
2.1E-05 |
2.3E-03 |
6.8E-01 |
|
Fcer1g |
Receptor |
12.7 |
0.7 |
0.7 |
7.4E-04 |
1.4E-02 |
2.2E-01 |
|
Ptger3 |
Receptor |
12.0 |
1.2 |
1.1 |
3.5E-04 |
2.3E-01 |
6.9E-01 |
|
Il12rb1 |
Receptor |
10.6 |
11.3 |
4.0 |
8.9E-04 |
2.7E-05 |
1.8E-02 |
|
Ltb4r1 |
Receptor |
8.8 |
1.2 |
0.9 |
2.9E-03 |
1.8E-01 |
7.0E-01 |
|
Gabarapl1 |
Receptor |
8.7 |
5.3 |
3.4 |
2.4E-04 |
1.8E-03 |
1.4E-01 |
|
Ly6a |
Receptor |
7.3 |
11.3 |
3.0 |
3.5E-04 |
1.7E-04 |
5.3E-02 |
|
Tcrg |
Receptor |
6.3 |
0.2 |
0.3 |
1.9E-03 |
1.4E-03 |
6.9E-02 |
|
Il12rb2 |
Receptor |
5.8 |
18.2 |
6.2 |
1.1E-04 |
1.6E-04 |
1.0E-02 |
|
Pilrb |
Receptor |
5.8 |
0.9 |
0.8 |
1.1E-03 |
1.5E-01 |
5.2E-01 |
|
Tmem2 |
Receptor |
5.8 |
4.6 |
2.0 |
5.4E-03 |
8.5E-04 |
1.1E-01 |
|
Gpr171 |
Receptor |
4.6 |
7.4 |
2.9 |
8.8E-03 |
1.3E-03 |
1.2E-01 |
|
Gpr34 |
Receptor |
4.5 |
0.6 |
0.7 |
2.7E-02 |
1.1E-02 |
3.6E-01 |
|
Gpr160 |
Receptor |
3.7 |
1.1 |
1.4 |
4.8E-03 |
3.0E-01 |
3.5E-01 |
|
Oprm1 |
Receptor |
0.20 |
0.08 |
0.49 |
1.6E-03 |
3.6E-04 |
1.1E-01 |
|
Tlr1 |
Receptor |
0.12 |
0.11 |
0.19 |
1.3E-04 |
3.5E-04 |
2.2E-02 |
|
Trat1 |
Receptor |
0.12 |
0.15 |
0.25 |
1.3E-04 |
2.2E-03 |
4.3E-02 |
|
Edg1 |
Receptor |
0.10 |
0.17 |
0.13 |
2.9E-04 |
1.0E-02 |
3.0E-02 |
|
Il2ra (CD25) |
CR |
48.4 |
66.9 |
28.1 |
1.7E-05 |
1.2E-05 |
2.7E-03 |
|
Il2rb (CD122) |
CR |
7.1 |
4.3 |
1.9 |
1.4E-03 |
1.4E-03 |
2.7E-01 |
|
Il7r |
CR |
0.12 |
0.17 |
0.05 |
3.4E-04 |
1.0E-04 |
4.9E-03 |
|
Il6ra |
CR |
0.11 |
0.26 |
0.16 |
6.3E-06 |
1.0E-02 |
9.2E-03 |
|
Il6st |
CR |
0.08 |
0.11 |
0.16 |
2.7E-07 |
3.7E-05 |
5.3E-03 |
|
Sema6d |
Costimulation |
6.1 |
0.9 |
1.4 |
2.1E-02 |
3.2E-01 |
2.5E-01 |
|
Pdcd1 |
Costimulation |
4.5 |
4.0 |
4.6 |
8.3E-03 |
5.2E-03 |
1.7E-02 |
|
Ptger2 |
Costimulation |
4.5 |
18.3 |
5.3 |
1.1E-04 |
6.8E-05 |
1.5E-02 |
|
Cd28 |
Costimulation |
4.0 |
6.3 |
2.2 |
2.0E-03 |
2.6E-04 |
1.1E-01 |
|
Cd80 |
Costimulation |
3.6 |
2.1 |
1.3 |
7.8E-03 |
5.3E-03 |
4.7E-01 |
|
Cd24a |
Costimulation |
0.03 |
0.82 |
0.78 |
4.2E-04 |
2.8E-01 |
6.4E-01 |
|
Ccr5 |
CCR |
18.3 |
3.9 |
1.6 |
1.1E-05 |
4.3E-04 |
1.4E-01 |
|
Ccr2 |
CCR |
15.7 |
0.7 |
0.5 |
2.4E-04 |
6.1E-02 |
4.0E-02 |
|
Cxcr6 |
CCR |
5.0 |
1.9 |
0.1 |
5.5E-03 |
1.9E-01 |
3.6E-02 |
|
Ccr7 |
CCR |
0.10 |
0.39 |
1.43 |
1.1E-03 |
6.2E-02 |
7.0E-01 |
|
Cxcr4 |
CCR |
0.06 |
0.46 |
0.10 |
6.3E-06 |
2.1E-02 |
9.2E-03 |
|
Ccr9 |
CCR |
0.03 |
0.03 |
0.04 |
3.1E-07 |
7.6E-06 |
2.7E-03 |
|
Adam8 |
Adhesion |
16.9 |
6.1 |
0.8 |
3.9E-04 |
4.4E-03 |
4.5E-01 |
|
Tjp1 |
Adhesion |
14.6 |
0.4 |
0.4 |
2.9E-05 |
6.7E-03 |
5.0E-02 |
|
Emp1 |
Adhesion |
14.4 |
13.7 |
1.3 |
1.2E-03 |
2.2E-03 |
6.3E-01 |
|
Emilin2 |
Adhesion |
13.6 |
0.8 |
1.1 |
2.4E-04 |
2.0E-01 |
7.6E-01 |
|
Itgav |
Adhesion |
10.6 |
3.6 |
2.3 |
3.6E-05 |
1.0E-03 |
8.1E-02 |
|
Nov |
Adhesion |
10.6 |
1.0 |
1.1 |
1.4E-02 |
4.3E-01 |
7.5E-01 |
|
Alcam |
Adhesion |
8.2 |
18.3 |
8.5 |
3.0E-04 |
2.9E-04 |
1.9E-02 |
|
Cdh1 |
Adhesion |
6.9 |
0.8 |
0.9 |
3.3E-03 |
8.6E-02 |
6.2E-01 |
|
Adam9 |
Adhesion |
6.9 |
7.1 |
2.3 |
4.0E-04 |
1.2E-03 |
2.6E-01 |
|
Tjp2 |
Adhesion |
5.7 |
4.7 |
2.0 |
1.8E-04 |
9.1E-05 |
1.0E-01 |
|
Dsc2 |
Adhesion |
5.0 |
0.9 |
0.9 |
5.8E-02 |
2.0E-01 |
7.1E-01 |
|
Itga6 |
Adhesion |
0.14 |
0.12 |
0.48 |
4.2E-04 |
1.6E-04 |
1.5E-01 |
|
Itgae |
Adhesion |
0.08 |
0.10 |
0.09 |
3.8E-06 |
7.1E-05 |
4.2E-03 |
|
Sell (CD62L) |
Adhesion |
0.04 |
0.23 |
0.19 |
2.4E-04 |
3.6E-04 |
1.4E-02 |
|
|
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|
NKT, CD8+ NKT-like cells; nCD8, naïve CD8+ T cells; cCD4, cultured CD4+ T cells; aCD8, activated CD8+ T cells. CCR, chemokine receptor; CR, cytokine receptor. |
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|
Zhou et al. Genome Biology 2008 9:R119 doi:10.1186/gb-2008-9-7-r119 |
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