Table 1

Recent genetic studies of complex diseases and traits in special populations
Complex disease/trait
 Gene/locus
 Population/isolate
 Reference
Affective disorders
 Several loci
 Northern Sweden
 [34]
Asthma
 IRAK-M (interleukin-1 receptor-associated kinase M)
 Sardinia
 [74]
Asthma
 CHI3L1 (chitinase 3-like 1)
 Hutterites
 [25]
Asthma
 NPSR1 (neuropeptide S receptor 1)
 Finland
 [24]
Atrial fibrillation
 4q25
 Iceland
 [11]
Bipolar disorder
 5q31-34
 Antioquia (Colombia), Central Valley of Costa Rica
 [29]
Bone mineral density
 Several loci
 Iceland
 [75]
Breast cancer
 5p12, 2q35, 16q12
 Iceland
 [76,77]
Myocardial infarction
 9p21
 Iceland
 [8,78]
Coronary heart disease
 8p22
 French Canadians
 [79]
Crohn's disease
 Several loci
 French Canadians
 [80]
Fasting glucose levels
 G6PC2 (glucose-6-phosphatase, catalytic, 2)/ABCB11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) region
 Finland, Sardinia
 [81]
Exfoliation glaucoma
 LOXL1 (lysyl oxidase-like 1)
 Iceland
 [82]
Height
 Several loci
 Iceland
 [13]
Height
 GDF5 (growth differentiation factor 5)/UQCC (ubiquinol-cytochrome c reductase complex chaperone) locus
 Finland, Sardinia, Amish
 [83]
Nicotine dependence and smoking-related diseases
 15q24
 Iceland
 [84]
Obesity
 FTO (fat mass and obesity associated), PFKP (phosphofructokinase, platelet)
 Sardinia
 [28]
Parkinson's disease
 GBA (β-glucocerebrosidase)
 Ashkenazi Jews
 [37]
Pigmentation
 Several genes
 Iceland
 [14,15]
Prostate cancer
 Xp11.22, 2p15, 17q
 Iceland
 [12,85]
Psychotic and bipolar spectrum disorders
 TSNAX (translin-associated factor X)/DISC1(disrupted in schizophrenia 1) locus
 Finland
 [86]
Psychosis
 TGIF (TGFB-induced factor)
 Central Valley of Costa Rica
 [87]
Schizophrenia
 DRD2 (dopamine D2 receptor)
 Basques
 [30]
Type 2 diabetes
 CDKAL1 (CDK5 regulatory subunit associated protein 1-like 1)
 Iceland
 [10]

Kristiansson et al. Genome Biology 2008 9:109   doi:10.1186/gb-2008-9-8-109