Table 2 |
|
|
Use of isolated versus outbred populations |
|
|
Benefits of population isolates |
Benefits of outbred populations |
|
|
|
|
Higher degree of LD |
More affected individuals |
|
Less areas of very low LD ('holes') |
More polymorphic markers |
|
Ability to map recessive genes |
More opportunity for replication |
|
Fewer number of causative alleles |
|
|
Good genealogical records |
|
|
More uniform environment |
|
|
Less migration |
|
|
More standardized phenotyping |
|
|
High participation rate in studies |
|
|
|
|
|
Kristiansson et al. Genome Biology 2008 9:109 doi:10.1186/gb-2008-9-8-109 |
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