Reduced-representation methylation mapping
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* Corresponding authors: Jeffrey A Jeddeloh jeffrey.jeddeloh@roche.com - Oliver J Rando Rando@umassmed.edu
1 Roche NimbleGen Inc., Research and Development, 500 S. Rosa Rd, Madison, WI 53719, USA
2 Center for Epigenomics and Department of Genetics (Division of Computational Genetics), Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA
3 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
Genome Biology 2008, 9:231 doi:10.1186/gb-2008-9-8-231
Published: 1 September 2008Abstract
The power of massively parallel sequencing has been harnessed to map cytosine methylation patterns in the mouse genome, allowing insights into the relationship of methylation with DNA sequence, histone modifications, transcriptional activity and dynamic changes in methylation status during differentiation.