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Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules

Eran Hodis127, Jaime Prilusky3, Eric Martz4, Israel Silman25, John Moult6 and Joel L Sussman12*

Author Affiliations

1 Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel

2 The Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 76100, Israel

3 Biological Services Unit, Weizmann Institute of Science, Rehovot 76100, Israel

4 Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA

5 Neurobiology Department, Weizmann Institute of Science, Rehovot 76100, Israel

6 Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA

7 Current Address: Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel

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Genome Biology 2008, 9:R121  doi:10.1186/gb-2008-9-8-r121

Published: 3 August 2008

Abstract

Many scientists lack the background to fully utilize the wealth of solved three-dimensional biomacromolecule structures. Thus, a resource is needed to present structure/function information in a user-friendly manner to a broad scientific audience. Proteopedia http://www.proteopedia.org webcite is an interactive, wiki web-resource whose pages have embedded three-dimensional structures surrounded by descriptive text containing hyperlinks that change the appearance (view, representations, colors, labels) of the adjacent three-dimensional structure to reflect the concept explained in the text.