Research
Novel genes dramatically alter regulatory network topology in amphioxus
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* Corresponding authors: Gary W Litman litmang@allkids.org - Adam Godzik adam@burnham.org
- † Equal contributors
1 Burnham Institute for Medical Research, North Torrey Pines Road, La Jolla, CA 92037, USA
2 Department of Molecular Genetics, All Children's Hospital, 6th Street South, St. Petersburg, FL 33701, USA
3 H Lee Moffitt Cancer Center and Research Institute, Magnolia Drive, Tampa, FL 33612, USA
4 School of Informatics, Indiana University, E. 10th Street, Bloomington, IN 47408, USA
5 Department of Pediatrics, University of South Florida, Children's Research Institute, First Street South, St. Petersburg, FL 33701, USA
6 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, Gilman Drive, La Jolla, CA 92093, USA
Genome Biology 2008, 9:R123 doi:10.1186/gb-2008-9-8-r123
Published: 4 August 2008Additional files
Additional data file 1:
TIR domain containing sequences in different genomes.
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Additional data file 2:
NACHT domain containing sequences in different genomes.
Format: PDF Size: 70KB Download file
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Additional data file 3:
SRCR domain combinations in different genomes.
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Additional data file 4:
Partner domains that combine with individual TIR or NACHT domains in different genomes.
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Additional data file 5:
Selected JGI-predicted amphioxus gene models that have been verified by RT-PCR.
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Additional data file 6:
Examples of novel domain combinations in amphioxus that represent the shortcuts between two or more proteins present in human.
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Additional data file 7:
Alignment of sequences in the vicinity of the catalytic center of the caspase domain from human caspases and amphioxus proteins with TNFR-caspase or LRRs-caspase architectures.
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