Difference between protein domain networks involving the TIR domain in amphioxus, human, and sea urchin. (a) A comparison by CADO of the domain network anchored by the TIR domain in human and sea urchin. (b) CADO picture anchored by the TIR domain between human and amphioxus. (c) CADO picture anchored by the TIR domain between amphioxus and sea urchin. A line connecting two domains indicates a predicted single protein domain combination. Common domain combinations between the selected genomes are shown in gray; amphioxus-specific combinations are shown in red; human-specific combinations are shown in blue; and sea urchin-specific combinations are shown in green. Please note that to simplify the graphical representation, Pfam clans are adopted for some Pfam domains. The CADO picture may differ slightly when different thresholds are used, for instance, the Ig-TIR domain combination can be found in sea urchin when using SMART domain definitions.
Zhang et al. Genome Biology 2008 9:R123 doi:10.1186/gb-2008-9-8-r123