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Metabolic changes in schizophrenia and human brain evolution

Philipp Khaitovich12*, Helen E Lockstone3, Matthew T Wayland3, Tsz M Tsang4, Samantha D Jayatilaka4, Arfu J Guo15, Jie Zhou16, Mehmet Somel12, Laura W Harris3, Elaine Holmes4, Svante Pääbo2 and Sabine Bahn3*

Author Affiliations

1 Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Yue Yang Road, Shanghai, 200031, PR China

2 Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz, D-04103 Leipzig, Germany

3 Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK

4 Department of Biomolecular Medicine, Division of SORA, Imperial College London, SW7 2AZ, UK

5 University of Science and Technology of China, Jinzhai Road, Hefei, 230026, PR China

6 Shanghai Jiao Tong University, Dongchuan Road, Shanghai, 200240, PR China

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Genome Biology 2008, 9:R124  doi:10.1186/gb-2008-9-8-r124

Published: 5 August 2008

Additional files

Additional data file 1:

Figure S1 shows the PCA of the metabolite abundance profile residuals in 33 individuals after sex and age linear regression. Figure S2 shows the bootstrap analysis of the ratio of human/chimpanzee lineage length. Figure S3 shows the extent of the LD and the recombination rate for genes associated with metabolites affected and not affected in schizophrenia. Table S1 lists sample information. Table S2 is a representation of schizophrenia-related expression changes in GO categories positively selected during human evolution. Table S3 lists GO groups showing excess of expression changes in both schizophrenia and human evolution. Table S4 provides 1H NMR spectra for 33 samples. Table S5 list the assignments of NMR spectra peaks to metabolites and metabolite groups. Table S6 lists genes associated with fast-evolving and slow-evolving metabolite groups. Table S7 lists mRNA expression of genes associated with metabolites significantly altered in schizophrenia. Table S8 lists mRNA expression of genes associated with metabolites not altered in schizophrenia.

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