Table 1

Detected metabolites and metabolite groups

Effect size


Metabolite group

Number of peaks*

t-test

p-value

Hsch/Hc

Hc/C

Hc/R


Creatine

2

0.000

2.3

-2.3

-4.9

Lactate

6

0.005

1.5

-2.7

-0.6

Phosphocholine

1

0.034

1.0

-1.4

-0.3

Glycerophosphocholine

1

0.042

1.0

-1.5

-0.7

N-acetylaspartate

5

0.040

0.9

-2.2

-1.8

Acetate

1

0.025

-1.1

-0.3

0.1

Glycine

1

0.024

-1.1

3.3

4.2

Choline

1

0.010

-1.4

4.0

3.4

Unknown§

6

0.002

-1.5

2.8

6.2

Taurine

3

0.080

Glutamate/glutamine 1§¶

4

0.114

Glutamate/glutamine 2

4

0.130

Glutamine§

4

0.280

Glutamate 1§¶

3

0.381

Scyllo-inositol

1

0.404

Gamma-aminobutyric acid

5

0.470

Myo-inositol

9

0.630

Glutamate/proline

1

0.710

Myo-inositol/taurine

3

0.797

Glutamate 2

5

0.841

N-acetylaspartylglutamate

1

0.845


*Number of peaks in the NMR spectrum corresponding to the metabolite/metabolite group. Comparison between metabolite concentrations in 10 human schizophrenia patients and 12 human control individuals. Effect size was calculated as the difference between means of metabolite concentrations between the groups normalized to the average standard deviation within the group. Positive values indicate higher concentration in group one, negative values higher concentration in group two. Hc, human controls; Hsch, human schizophrenia patients; C, chimpanzees; R, rhesus macaques. §These peaks show a high degree of spectral overlap with other unidentified baseline peaks. Glutamine/glutamate and glutamate peaks were separated into two independent groups based on the intensity correlation analysis (see Materials and methods).

Khaitovich et al. Genome Biology 2008 9:R124   doi:10.1186/gb-2008-9-8-r124

Open Data