Dynamic simulation of regulation of duplucate genes by microRNA. (a) A schematic diagram of a hypothetical microRNA-mediated regulatory circuit involving duplicate genes. A detailed explanation of the elements is in the main text. (b) Simulation of a microRNA-mediated regulatory circuit as depicted in (a). Prior to the null mutation on T2 at time point 20, the level of T1 is repressed by microRNA M, and the expression of P is mainly regulated by T2. After the null mutation on T2, T1 is up-regulated, which in turn restores P up to its original level.
Li et al. Genome Biology 2008 9:R132 doi:10.1186/gb-2008-9-8-r132