The telosome/shelterin complex and its functions
1 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA
2 Cell-Based Assay Screening Service Core, Baylor College of Medicine, Houston, TX 77030, USA
Genome Biology 2008, 9:232 doi:10.1186/gb-2008-9-9-232Published: 18 September 2008
The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions.