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Review

The telosome/shelterin complex and its functions

Huawei Xin1, Dan Liu12 and Zhou Songyang1*

Author Affiliations

1 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA

2 Cell-Based Assay Screening Service Core, Baylor College of Medicine, Houston, TX 77030, USA

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Genome Biology 2008, 9:232  doi:10.1186/gb-2008-9-9-232

Published: 18 September 2008

Abstract

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions.