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Modeling synthetic lethality

Nolwenn Le Meur12* and Robert Gentleman1

Author Affiliations

1 Fred Hutchinson Cancer Center Research, Program in Computational Biology, Division of Public Health Sciences, Fairview Avenue North, Seattle, WA 98109, USA

2 INSERM, IRISA Symbiose, Campus de Beaulieu, 35042 RENNES Cedex, France

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Genome Biology 2008, 9:R135  doi:10.1186/gb-2008-9-9-r135

Published: 12 September 2008

Additional files

Additional data file 1:

Detailed information about the data sources used in the main manuscript. We also present and discuss additional analysis performed for comparison with the results presented in the main paper.

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Additional data file 2:

Each file has 13 columns: P and P-values (adjusted), P-values and adjusted P-values of the hypergeometric test; Odds, odds ratios; Expected,: expected number of synthetic genetic interactions between complexes; Interact (observed), number of synthetic genetic interactions observed; Tested, number of interaction tested; Essential genes, number of essential genes in complexes 1 and 2, respectively; Size, number of proteins in each complex; Names, full name of each complex. Note that when all the tested interactions are found to be synthetic genetic interactions (tested = interact), the odds ratios are infinite (Inf).

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