Within multi-protein complex versus between multi-protein complex synthetic lethal interactions. The kinetochore complexes are composed of sub-complexes that present many synthetic lethal interactions, especially between them. In bold are proteins that are part of either the kinetochore complex [GO:0000776] or the condensed nuclear chromosome kinetochore [GO:0000778]. In italics are the proteins that are not currently listed as part of those kinetochore complexes. The essential genes are labeled in red. The observed synthetic genetic interactions are indicated by a red line. The number associated with a red line indicates the number of synthetic genetic interactions within or between the sub-complexes. Most of the synthetic genetic interactions are between sub-complexes that contain few or no essential genes. Systematic names for these genes are available in Additional data file 1.
Le Meur and Gentleman Genome Biology 2008 9:R135 doi:10.1186/gb-2008-9-9-r135