Table 2

Top 10 pairs of multi-protein complexes that present 'between' synthetic genetic interactions






Essential genes






Complex 1/complex 2
 P-values (adjusted)
 Odds
 Expected
 Interact
 Tested
 Complex 1
 Complex 2
Condensed kinetochore [GO:0000778]/prefoldin [GO:0016272]
 5.54e-86
 350.66
 0.50
 49
 68
 19
 0
Outer kinetochore [MIPS-270.20]/prefoldin [GO:0016272]
 1.51e-72
 Inf
 0.26
 35
 35
 12
 0
Prefoldin [GO:0016272]/SWR1 [GO:0000812]
 7.05e-50
 326.96
 0.30
 29
 41
 0
 5
Ctf3 [GO:0016272]/prefoldin [GO:0005868]
 1.61e-36
 674.97
 0.18
 20
 24
 0
 0
Prefoldin [MIPS-270.20.20]/cytoplasmic dynein [GO:0016272]
 7.23e-30
 Inf
 0.11
 15
 15
 0
 0
Ctf18 RFC-like [GO:0016272]/prefoldin [GO:0005869]
 5.78e-27
 674. 13
 0.13
 15
 18
 0
 0
Prefoldin [GO:0031390]/Dynactin [GO:0016272]
 5.78e-27
 674. 13
 0.13
 15
 18
 4
 0
Dynein motorproteins [MIPS-140.30.30.20]/prefoldin [GO:0016272]
 5.78e-27
 674. 13
 0.13
 15
 18
 0
 0
Dynactin [MIPS-140.30.30.30]/prefoldin [GO:0016272]
 5.78e-27
 674. 13
 0.13
 15
 18
 0
 0
Kinetochore [GO:0000776]/condensed kinetochore [GO:0000778]
 3.24e-25
 85.47
 0.36
 19
 49
 7
 19

Top 10 pairs of multi-protein complexes that present between synthetic genetic interactions in Tong et al. [10]. P-values (adjusted), Bonferroni adjusted P-value of the hypergeometric test; Odds, odds ratios; Expected, expected number of synthetic genetic interactions between multi-protein complexes; Interact, number of synthetic genetic interactions observed (positive edges); Tested, number of interactions (edges) tested; Essential genes, number of essential genes in multi-protein complexes 1 and 2, respectively. Note that when all the tested interactions are synthetic genetic interactions (tested = interact) the odds ratios are infinite (Inf).

Le Meur and Gentleman Genome Biology 2008 9:R135   doi:10.1186/gb-2008-9-9-r135

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