Table 2

Top 10 pairs of multi-protein complexes that present 'between' synthetic genetic interactions

Essential genes


Complex 1/complex 2

P-values (adjusted)

Odds

Expected

Interact

Tested

Complex 1

Complex 2


Condensed kinetochore [GO:0000778]/prefoldin [GO:0016272]

5.54e-86

350.66

0.50

49

68

19

0

Outer kinetochore [MIPS-270.20]/prefoldin [GO:0016272]

1.51e-72

Inf

0.26

35

35

12

0

Prefoldin [GO:0016272]/SWR1 [GO:0000812]

7.05e-50

326.96

0.30

29

41

0

5

Ctf3 [GO:0016272]/prefoldin [GO:0005868]

1.61e-36

674.97

0.18

20

24

0

0

Prefoldin [MIPS-270.20.20]/cytoplasmic dynein [GO:0016272]

7.23e-30

Inf

0.11

15

15

0

0

Ctf18 RFC-like [GO:0016272]/prefoldin [GO:0005869]

5.78e-27

674. 13

0.13

15

18

0

0

Prefoldin [GO:0031390]/Dynactin [GO:0016272]

5.78e-27

674. 13

0.13

15

18

4

0

Dynein motorproteins [MIPS-140.30.30.20]/prefoldin [GO:0016272]

5.78e-27

674. 13

0.13

15

18

0

0

Dynactin [MIPS-140.30.30.30]/prefoldin [GO:0016272]

5.78e-27

674. 13

0.13

15

18

0

0

Kinetochore [GO:0000776]/condensed kinetochore [GO:0000778]

3.24e-25

85.47

0.36

19

49

7

19


Top 10 pairs of multi-protein complexes that present between synthetic genetic interactions in Tong et al. [10]. P-values (adjusted), Bonferroni adjusted P-value of the hypergeometric test; Odds, odds ratios; Expected, expected number of synthetic genetic interactions between multi-protein complexes; Interact, number of synthetic genetic interactions observed (positive edges); Tested, number of interactions (edges) tested; Essential genes, number of essential genes in multi-protein complexes 1 and 2, respectively. Note that when all the tested interactions are synthetic genetic interactions (tested = interact) the odds ratios are infinite (Inf).

Le Meur and Gentleman Genome Biology 2008 9:R135   doi:10.1186/gb-2008-9-9-r135

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