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Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

Johan Staaf12, David Lindgren1, Johan Vallon-Christersson12, Anders Isaksson3, Hanna Göransson3, Gunnar Juliusson4, Richard Rosenquist5, Mattias Höglund1, Åke Borg124 and Markus Ringnér12*

Author Affiliations

1 Department of Oncology, Clinical Sciences, Lund University, SE-22185 Lund, Sweden

2 CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, SE-22184 Lund, Sweden

3 Department of Medical Sciences, Cancer Pharmacology and Informatics, Uppsala University, SE-75185 Uppsala, Sweden

4 Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, SE-22184 Lund, Sweden

5 Department of Genetics and Pathology, Uppsala University, SE-75185 Uppsala, Sweden

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Genome Biology 2008, 9:R136  doi:10.1186/gb-2008-9-9-r136

Published: 16 September 2008

Additional files

Additional data file 1:

Implementation of the segmentation approach and analysis using the approach.

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Additional data file 2:

Results using triplet filtering.

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Additional data file 3:

Generation and analysis of the simulated data set.

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Additional data file 4:

Analysis of experimental data available at the project web site [35].

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