Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

Johan Staaf^1,2 , David Lindgren¹ , Johan Vallon-Christersson^1,2 , Anders Isaksson³ , Hanna Göransson³ , Gunnar Juliusson⁴ , Richard Rosenquist⁵ , Mattias Höglund¹ , Åke Borg^1,2,4 and Markus Ringnér^1,2

¹  Department of Oncology, Clinical Sciences, Lund University, SE-22185 Lund, Sweden

²  CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, SE-22184 Lund, Sweden

³  Department of Medical Sciences, Cancer Pharmacology and Informatics, Uppsala University, SE-75185 Uppsala, Sweden

⁴  Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, SE-22184 Lund, Sweden

⁵  Department of Genetics and Pathology, Uppsala University, SE-75185 Uppsala, Sweden