Table 4

Estimation of tumor cell sub-clone content by segmentation for hemizygous loss in CLL samples

Sample*

CLL cells (%)

Genomic region

Hemizygous loss by FISH (%)

Hemizygous loss by segmentation (%)


8

87

17p13.3-p11.1

73

77

9

90

11q22.1-q23.3

56

58

10

86

17p13.3-p11.2

90

94


*Data set 4. mBAF cut-off for each sample based on the maximum theoretical value for copy neutral LOH for the respective tumor content. Percent CLL cells (CD5+/CD23+) were estimated by flow cytometry. The average segmented value for the region was used.

Staaf et al. Genome Biology 2008 9:R136   doi:10.1186/gb-2008-9-9-r136

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