Table 4

Estimation of tumor cell sub-clone content by segmentation for hemizygous loss in CLL samples

Sample*

CLL cells (%)^†

Genomic region

Hemizygous loss by FISH (%)

Hemizygous loss by segmentation (%)^‡

8

87

17p13.3-p11.1

73

77

9

90

11q22.1-q23.3

56

58

10

86

17p13.3-p11.2

90

94

*Data set 4. mBAF cut-off for each sample based on the maximum theoretical value for copy neutral LOH for the respective tumor content. ^†Percent CLL cells (CD5⁺/CD23⁺) were estimated by flow cytometry. ^‡The average segmented value for the region was used.

Staaf et al. Genome Biology 2008 9:R136   doi:10.1186/gb-2008-9-9-r136