Genome Biology

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Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang, Tao Liu, Clifford A Meyer, Jérôme Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li* and X Shirley Liu*

Genome Biology 2008, 9:R137 doi:10.1186/gb-2008-9-9-r137

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Proceedings   Open Access

A signal processing approach for enriched region detection in RNA polymerase II ChIP-seq data

Zhi Han, Lu Tian, Thierry Pécot, Tim Huang, Raghu Machiraju, Kun Huang BMC Bioinformatics 2012, 13(Suppl 2):S2 (13 March 2012)

Research article   Open Access

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

Hansook Kim Chong, Jacob Biesinger, Young-Kyo Seo, Xiaohui Xie, Timothy F Osborne BMC Genomics 2012, 13:51 (1 February 2012)

Research article   Open Access

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

Petri Pehkonen, Lynn Welter-Stahl, Janine Diwo, Jussi Ryynanen, Anke Wienecke-Baldacchino, Sami Heikkinen, Eckardt Treuter, Knut R Steffensen, Carsten Carlberg BMC Genomics 2012, 13:50 (31 January 2012)

Proceedings   Open Access

Improving ChIP-seq peak-calling for functional co-regulator binding by integrating multiple sources of biological information

Hatice Osmanbeyoglu, Ryan J Hartmaier, Steffi Oesterreich, Xinghua Lu BMC Genomics 2012, 13(Suppl 1):S1 (17 January 2012)

Research   Open Access

A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements

Stefan Enroth, Claes R Andersson, Robin Andersson, Claes Wadelius, Mats G Gustafsson, Jan Komorowski Algorithms for Molecular Biology 2012, 7:2 (16 January 2012)

Proceedings   Open Access

Pinpointing transcription factor binding sites from ChIP-seq data with SeqSite

Xi Wang, Xuegong Zhang BMC Systems Biology 2011, 5(Suppl 2):S3 (14 December 2011)

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A co-ordinated interaction between CTCF and ER in breast cancer cells

Caryn S Ross-Innes, Gordon D Brown, Jason S Carroll BMC Genomics 2011, 12:593 (5 December 2011)

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Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements

Morten Rye, Pål Sætrom, Tony Håndstad, Finn Drabløs BMC Biology 2011, 9:80 (24 November 2011)

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Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data

Iros Barozzi, Alberto Termanini, Saverio Minucci, Gioacchino Natoli Biology Direct 2011, 6:51 (6 October 2011)

Fish the ChIPs is a computational pipeline for complete ChIP-Seq data analysis of unlimited samples; it can be run on any Unix machine while providing a graphic interface for Mac.

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Cistrome: an integrative platform for transcriptional regulation studies

Tao Liu, Jorge A Ortiz, Len Taing, Clifford A Meyer, Bernett Lee, Yong Zhang, Hyunjin Shin, Swee S Wong, Jian Ma, Ying Lei, Utz J Pape, Michael Poidinger, Yiwen Chen, Kevin Yeung, Myles Brown, Yaron Turpaz, X Shirley Liu Genome Biology 2011, 12:R83 (22 August 2011)

A Galaxy-based web application for integrative analysis of ChIP data

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Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development

Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily SW Wong, Christophe M Lefèvre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R Short, Hannah V Siddle, Stephen R Frankenberg, Keng Chew, Brandon R Menzies, Jessica M Stringer, Shunsuke Suzuki, Timothy A Hore, Margaret L Delbridge et al. Genome Biology 2011, 12:R81 (19 August 2011)

This article is part of a collection on The tammar wallaby genome...

The tammar wallaby genome and transcriptome sequences yield insights into many aspects of mammalian biology

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An integrated strategy for identification of both sharp and broad peaks from next-generation sequencing data

Weiqun Peng, Keji Zhao Genome Biology 2011, 12:120 (25 July 2011)

Keji Zhao discusses Genome Biology's method article on ZINBA, a novel peak-finding tool developed by Jason Lieb and colleagues

Method   Open Access Highly Accessed

ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions

Naim U Rashid, Paul G Giresi, Joseph G Ibrahim, Wei Sun, Jason D Lieb Genome Biology 2011, 12:R67 (25 July 2011)

ZINBA is a method for analyzing peaks in next generation sequencing datasets such as ChIP-seq or DNase-seq

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An integrated ChIP-seq analysis platform with customizable workflows

Eugenia G Giannopoulou, Olivier Elemento BMC Bioinformatics 2011, 12:277 (7 July 2011)

Research   Open Access

Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer

Phillip WL Tai, Katherine I Fisher-Aylor, Charis L Himeda, Catherine L Smith, Alexandra P MacKenzie, Deri L Helterline, John C Angello, Robert E Welikson, Barbara J Wold, Stephen D Hauschka Skeletal Muscle 2011, 1:25 (7 July 2011)

Research   Open Access

Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis

Shaun Mahony, Esteban O Mazzoni, Scott McCuine, Richard A Young, Hynek Wichterle, David K Gifford Genome Biology 2011, 12:R2 (13 January 2011)

ChIP-seq for retinoic acid receptor binding during early neuronal differentiation reveals a complex landscape of transcriptional control.

Research article   Open Access

Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells

Igor Martianov, Mohamed-Amin Choukrallah, Arnaud Krebs, Tao Ye, Stephanie Legras, Erikjan Rijkers, Wilfred Van Ijcken, Bernard Jost, Paolo Sassone-Corsi, Irwin Davidson BMC Genomics 2010, 11:530 (29 September 2010)

Method   Open Access Highly Accessed

Estimating enrichment of repetitive elements from high-throughput sequence data

Daniel S Day, Lovelace J Luquette, Peter J Park, Peter V Kharchenko Genome Biology 2010, 11:R69 (28 June 2010)

The authors present a method for estimating repetitive sequence content in high-throughput sequencing data, including from ChIP-seq experiments

Question & Answer   Open Access Highly Accessed

Q&A: ChIP-seq technologies and the study of gene regulation

Edison T Liu, Sebastian Pott, Mikael Huss BMC Biology 2010, 8:56 (14 May 2010)

Edison Liu and colleagues explain in Q&A format how ChIP-seq technology allows investigation of transcriptional regulation on a genomic scale, and what is next.

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ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

Lihua J Zhu, Claude Gazin, Nathan D Lawson, Hervé Pagès, Simon M Lin, David S Lapointe, Michael R Green BMC Bioinformatics 2010, 11:237 (11 May 2010)

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Evidence-ranked motif identification

Stoyan Georgiev, Alan P Boyle, Karthik Jayasurya, Xuan Ding, Sayan Mukherjee, Uwe Ohler Genome Biology 2010, 11:R19 (15 February 2010)

A new computational method for the identification of regulatory motifs from large genomic datasets is presented here

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An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data

Congmao Wang, Jie Xu, Dasheng Zhang, Zoe A Wilson, Dabing Zhang BMC Bioinformatics 2010, 11:81 (9 February 2010)

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A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data

Desmond S Lun, Ashley Sherrid, Brian Weiner, David R Sherman, James E Galagan Genome Biology 2009, 10:R142 (22 December 2009)

CSdeconv is a novel method for determining the location of transcription factor binding from ChIP-seq data that discriminates closely-spaced sites.

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A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments

Teemu D Laajala, Sunil Raghav, Soile Tuomela, Riitta Lahesmaa, Tero Aittokallio, Laura L Elo BMC Genomics 2009, 10:618 (18 December 2009)

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Identifying Positioned Nucleosomes with Epigenetic Marks in Human from ChIP-Seq

Yong Zhang, Hyunjin Shin, Jun S Song, Ying Lei, X Shirley Liu BMC Genomics 2008, 9:537 (13 November 2008)