Boxplots of correlations between the replicated samples after each step of the data normalization process. All boxes for which notches do not overlap vertically have significantly (α = 0.05) different median values. On the left is a sample set from 14 human muscle biopsy samples measured with array generations U95Av2 and U133A. The correlations computed based on the QAGC-normalized data are significantly higher when compared to MAS5 and Q methods. On the right, all correlations between 123 leukemia samples are plotted. The samples are from three different array generations U95Av2, U133A, and U133B. The first column illustrates correlations between all replicates together (369 correlation values), and in the other columns the correlations are grouped based on the array generation pairs. When the mean values of the correlations computed with each method were compared, the values in the QAGC data were significantly higher.
Kilpinen et al. Genome Biology 2008 9:R139 doi:10.1186/gb-2008-9-9-r139