Table 1 |
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The 21 brain regions examined in this study and their characteristics |
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Index |
Brain tissue |
Developmental origin |
Median ER (human lineage) |
Median ER (mouse-human) |
Frequency of mammalian genes |
Frequency of mammalian genes for SCS |
Frequency of primate genes |
Brain region specificity index (Tmax) |
Correlation (P value) between ER and expression level (human-mouse) |
|
|
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|
1 |
Dorsal root ganglion |
Spinal cord |
0.31 |
0.167 |
0.17 |
0.12 |
0.016248 |
0.12 |
-0.0747 (1.4 × 10-14) |
|
2 |
Medulla oblongata |
Hindbrain |
0.28 |
0.102 |
0.12 |
0.14 |
0.005525 |
0.1 |
-0.1844 (<10-16) |
|
3 |
Pons |
Hindbrain |
0.27 |
0.13 |
0.17 |
0.13 |
0.013158 |
0.11 |
-0.1442 (<10-16) |
|
4 |
Spinal cord |
Spinal cord |
0.25 |
0.127 |
0.13 |
0.16 |
0.003704 |
0.11 |
-0.1664 (<10-16) |
|
5 |
Olfactory bulb |
Subpallium (forebrain) |
0.28 |
0.126 |
0.09 |
0.08 |
0 |
0.14 |
-0.1475 (<10-16) |
|
6 |
Trigeminal ganglion |
Different developmental origin |
0.31 |
0.161 |
0.17 |
0.17 |
0.021223 |
0.12 |
-0.0445 (4.7 × 10-6) |
|
7 |
Ciliary ganglion |
Different developmental origin |
0.29 |
0.154 |
0.14 |
0.12 |
0.015152 |
0.12 |
-0.0710 (2.6 × 10-13) |
|
8 |
Superior cervical ganglion |
Different developmental origin |
0.31 |
0.161 |
0.16 |
0.13 |
0.013664 |
0.12 |
-0.0335 (5.7 × 10-4) |
|
9 |
Cerebellum |
Hindbrain |
0.14 |
0.083 |
0.08 |
0.09 |
0.004357 |
0.11 |
-0.1799 (<10-16) |
|
10 |
Cerebellum peduncles |
Hindbrain |
0.17 |
0.096 |
0.08 |
0.09 |
0.005102 |
0.12 |
-0.1846 (<10-16) |
|
11 |
Hypothalamus |
Diencephalon (forebrain) |
0.27 |
0.12 |
0.08 |
0.08 |
0 |
0.11 |
-0.1922 (<10-16) |
|
12 |
Thalamus |
Diencephalon (forebrain) |
0.19 |
0.103 |
0.1 |
0.04 |
0 |
0.10 |
-0.1903 (<10-16) |
|
13 |
Subthalamic nucleus |
Diencephalon (forebrain) |
0.23 |
0.11 |
0.14 |
0.2 |
0.005362 |
0.10 |
-0.1811 (<10-16) |
|
14 |
Caudate nucleus |
Subpallium (forebrain) |
0.26 |
0.105 |
0.09 |
0 |
0 |
0.11 |
-0.1817 (<10-16) |
|
15 |
Globus pallidus |
Subpallium (forebrain) |
0.23 |
0.107 |
0.12 |
0.1 |
0.010753 |
0.1 |
-0.1733 (<10-16) |
|
16 |
Amygdala |
Subpallium (forebrain) |
0.21 |
0.084 |
0.09 |
0.11 |
0.002151 |
0.1 |
-0.2294 (<10-16) |
|
17 |
Cingulate cortex |
Pallium (forebrain) |
0.2 |
0.094 |
0.07 |
0.05 |
0 |
0.1 |
-0.1931 (<10-16) |
|
18 |
Occipital lobe |
(pallium) (forebrain) |
0.2 |
0.089 |
0.05 |
0 |
0 |
0.09 |
-0.2199 (<10-16) |
|
19 |
Parietal lobe |
Pallium (forebrain) |
0.22 |
0.119 |
0.1 |
0.14 |
0 |
0.1 |
-0.1893 (<10-16) |
|
20 |
Temporal lobe |
Pallium (forebrain) |
0.21 |
0.104 |
0.13 |
0.1 |
0.006897 |
0.11 |
-0.2214 (<10-16) |
|
21 |
Prefrontal cortex |
Pallium (forebrain) |
0.22 |
0.089 |
0.08 |
0.06 |
0.002299 |
0.1 |
-0.1747 (<10-16) |
|
|
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|
ER, evolutionary rate; SCS, specific characteristic set. |
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|
Tuller et al. Genome Biology 2008 9:R142 doi:10.1186/gb-2008-9-9-r142 |
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