Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function

Weidong Tian¹, Lan V Zhang^1,4, Murat Taşan¹, Francis D Gibbons^1,5, Oliver D King^1,6, Julie Park², Zeba Wunderlich^1,7, J Michael Cherry² and Frederick P Roth^1,3

¹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA

²Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305-5120, USA

³Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Jimmy Fund Way, Boston, Massachusetts 02115, USA

⁴McKinsey and Company, Hansen Way, Palo Alto, California 94304, USA

⁵Merrimack Pharmaceuticals, Kendall Square, Cambridge, Massachusetts 02139, USA

⁶Boston Biomedical Research Institute (BBRI), Grove St., Watertown, Massachusetts 02472, USA

⁷Massachusetts Institute of Technology, Massachusetts Ave, Cambridge, Massachusetts 02139, USA