Integrating sequence, evolution and functional genomics in regulatory genomics

doi:10.1186/gb-2009-10-1-202

Genome Biology

Volume 10
Issue 1

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Vingron M
Brazma A
Coulson R
van Helden J
Manke T
Palin K
Sand O
Ukkonen E

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Brazma A
Coulson R
van Helden J
Manke T
Palin K
Sand O
Ukkonen E
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Review

Integrating sequence, evolution and functional genomics in regulatory genomics

Martin Vingron¹ , Alvis Brazma², Richard Coulson², Jacques van Helden³, Thomas Manke¹, Kimmo Palin⁴, Olivier Sand³ and Esko Ukkonen⁵

¹Computational Molecular Biology, Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany

²Microarray Group, European Bioinfomatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

³BiGRe - Université Libre de Bruxelles, Campus Plaine, Bvd du Triomphe - CP263, B-1050 Bruxelles, Belgium

⁴Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

⁵Helsinki Institute for Information Technology, Helsinki University of Technology and University of Helsinki, 00014 Helsinki, Finland

author email corresponding author email

Genome Biology 2009, 10:202doi:10.1186/gb-2009-10-1-202


Published:	30 January 2009

Subject areas: Bioinformatics, Methods, Genome studies

Abstract

With genome analysis expanding from the study of genes to the study of gene regulation, 'regulatory genomics' utilizes sequence information, evolution and functional genomics measurements to unravel how regulatory information is encoded in the genome.