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Review

Integrating sequence, evolution and functional genomics in regulatory genomics

Martin Vingron1*, Alvis Brazma2, Richard Coulson2, Jacques van Helden3, Thomas Manke1, Kimmo Palin4, Olivier Sand3 and Esko Ukkonen5

Author Affiliations

1 Computational Molecular Biology, Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany

2 Microarray Group, European Bioinfomatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

3 BiGRe - Université Libre de Bruxelles, Campus Plaine, Bvd du Triomphe - CP263, B-1050 Bruxelles, Belgium

4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

5 Helsinki Institute for Information Technology, Helsinki University of Technology and University of Helsinki, 00014 Helsinki, Finland

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Genome Biology 2009, 10:202  doi:10.1186/gb-2009-10-1-202

Published: 30 January 2009

Abstract

With genome analysis expanding from the study of genes to the study of gene regulation, 'regulatory genomics' utilizes sequence information, evolution and functional genomics measurements to unravel how regulatory information is encoded in the genome.