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Regulating highly dynamic unstructured proteins and their coding mRNAs

Buyong Ma1 and Ruth Nussinov12*

Author Affiliations

1 Basic Research Program, SAIC-Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA

2 Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Genome Biology 2009, 10:204  doi:10.1186/gb-2009-10-1-204

Published: 28 January 2009

Abstract

The lifetimes and conformations of intrinsically unstructured proteins (IUPs) and their mRNAs are orchestrated to ensure precision, speed and flexibility in biological control.