Genome Biology

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Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells

Britta Hartmann1,2*, Robert Castelo2,3, Marco Blanchette4,6, Stephanie Boue1,2,7, Donald C Rio4 and Juan Valcárcel1,2,5*

Author Affiliations

1 Centre de Regulació Genòmica, Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, Barcelona, 08003, Spain

2 Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, Barcelona, 08003, Spain

3 Institut Municipal D'Investigació Mèdica, Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, Barcelona, 08003, Spain

4 Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA

5 Institució Catalana de Recerca i Estudis Avançats, Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, Barcelona, 08003, Spain

6 Current address: Stowers Institute for Medical Research, E. 50th Street, Kansas City, 64110, USA

7 Current address: Centre de Medicina Regenerativa de Barcelona, Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, Barcelona, 08003, Spain

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Genome Biology 2009, 10:R11 doi:10.1186/gb-2009-10-1-r11

Published: 29 January 2009

Additional files

Additional data file 1:

Calculated Z-scores values from the microarray experiments, for each biological replicate, for genes that are transcriptionally regulated by the insulin (top) and wingless (bottom) signaling pathways.

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Open Data

Additional data file 2:

Calculated Z-scores for splice junction probes that are regulated upon induction of the insulin (top) and wingless (bottom) signaling pathways.

Format: PDF Size: 22KB Download file

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Open Data

Additional data file 3:

The table represents the percentage of enriched GO categories for genes regulated at the level of alternative splicing by (A) insulin and (B) wingless.

Format: PDF Size: 23KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data