Table 4 |
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|
Examples of genes encoding modulators of signaling pathways that show changes in splice junctions upon wingless pathway activation |
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|
Gene name |
Type of AS |
Effect of AS |
Expression |
Function |
|
|
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|
rotound |
Exon skipping |
Alternative coding sequence |
No change |
wingless expression regulation |
|
syndecan |
Alternative 3' splice site |
Alternative 5' UTR |
Upregulated |
Heparan sulfate proteoglycan |
|
IP3k2 |
Alternative 5' splice site |
Alternative 5' UTR |
Upregulated |
Inositol 3P 3-ki-nase activity |
|
sprint |
Alternative promoter; Alternative polyadenyl. |
Alternative VPS9 and Ras-association |
Potentially upregulated |
Ras GTPase binding |
|
cdep |
Exon skipping |
Alternative Ferm_3 domain |
No change |
Regulation of Rho signaling |
|
pink1 |
Alternative 3' splice site |
Alternative 5' UTR |
No change |
Serine/threonine kinase |
|
CG15611 |
Exon skipping |
Alternative coding sequence |
Downregulated |
Regulation of Rho signaling |
|
smi35A |
Complex exon skipping |
Alternative 5' UTR |
Upregulated |
Tyr-phosphorylation regulated kinase |
|
eip63E |
Alternative promoter |
Alternative 5' UTR and coding sequence |
Upregulated |
Cyclin-dependent protein kinase |
|
|
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|
Modulators of signaling activities are described, together with the type of alternative splicing event, predicted consequences for the transcript/protein and function in the pathway (as retrieved from Flybase and literature). AS, alternative splicing. |
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|
Hartmann et al. Genome Biology 2009 10:R11 doi:10.1186/gb-2009-10-1-r11 |
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