Figure 8.

The same miRNA family plays roles in different modes in different species. Locust, fruit fly and human have the same targets if only the 'seed' sequence is used for target recognition. If the 'seed' and region A work together, mir-8 can regulate different targets in insects and human. If the 'seed' and region B work together, mir-8 in these three species can regulate species-specific targets. hsa-miR-200b belongs to the family of mir-8.