The canonical -1, NFR, +1, +2, etc. nucleosome organization around the TSS is preserved in all datasets. (a) Illustration pointing out the -1, 0, +1 zones for systematic naming of nucleosome positions. Also shown is the distance from the TSS to the -1 and +1 nucleosomes. (b) Distribution of nucleosome calls in each of the six datasets around the TSS. Only nucleosomes having >50% occupancy were considered. The reference set is shown as a gray-filled plot. Note that sets 5 and 6 represent hidden Markov modeling or Pearson best fit of tiling array data, and thus represent modeled positions, based upon measured periodicities. Consensus positioning at further distances from the TSS may be artificially maintained in those datasets.
Jiang and Pugh Genome Biology 2009 10:R109 doi:10.1186/gb-2009-10-10-r109