Research
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis
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* Corresponding author: Vladimir Pelicic v.pelicic@imperial.ac.uk
- † Equal contributors
1 Génomique des Microorganismes Pathogènes, Institut Pasteur, rue du Dr Roux, Paris, 75015, France
2 Génomique Métabolique, CNRS UMR8030, Laboratoire de Génomique Comparative, CEA-Institut de Génomique-Génoscope, rue Gaston Crémieux, Evry, 91057, France
3 U570 INSERM, Faculté de Médecine René Descartes-Paris 5, rue de Vaugirard, Paris, 75015, France
4 Department of Microbiology, CMMI, Imperial College London, Armstrong Road, London, SW7 2AZ, UK
5 Current address: Biologie des Bactéries Intracellulaires, Institut Pasteur, rue du Dr Roux, Paris, 75015, France
6 Current address: Mutabilis, Parc Biocitech, avenue Gaston Roussel, Romainville, 93230, France
7 Current address: FAB pharma, rue Saint Honoré, Paris, 75001, France
Genome Biology 2009, 10:R110 doi:10.1186/gb-2009-10-10-r110
Published: 9 October 2009Additional files
Additional data file 1:
Strand conservation is indicated in purple, while strand inversions (because of chromosomal inversions) are in blue. Except in strain α14 where there is conserved colinearity, synteny is mainly disrupted by a single chromosomal inversion between the two genes that are indicated. For the 8013/Z2491 comparison, the readout is more difficult because the start of the Z2491 genome was not assigned at the origin of replication. Plots were generated using the LinePlot program within MicroScope after setting the minimum synton size to 40 genes.
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Additional data file 2:
Genes disrupted through targeted mutagenesis are shaded in light blue.
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Additional data file 3:
These genes, which are in synteny and/or are BBHs, encode proteins displaying at least 30% amino acid identity over at least 80% of their length.
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Additional data file 4:
For each GI, the first and the last gene are indicated, together with a comment about their putative roles.
Format: XLS Size: 53KB Download file
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