Figure 9.

Illustration of criteria for selection of candidate CNV regions. In this figure, the red lines tangent to the signal curve indicate the marker points that are elements of the sets D_max and D_min. (a) Q_ij violates the first condition, which requires that the start and end markers be elements of D_max and D_min, respectively. (b) Q_ij violates the second condition, which dictates that at least one marker must exceed the T_gain threshold value. (c) Q_ij does not satisfy the third condition since three markers of D_min appear before two markers of D_max in region Q_ij. (d) Q_ij violates the fourth condition, which requires that Q_ij is a maximal set satisfying all the first three conditions.