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Transcriptional regulation of metastatic [Id]entity by KLF17

Marcin P Iwanicki and Joan S Brugge*

Author Affiliations

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA

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Genome Biology 2009, 10:244  doi:10.1186/gb-2009-10-11-244

Published: 30 November 2009

Abstract

A novel in vivo screening approach has identified KLF17 as a key metastasis suppressor gene that acts through regulation of Id1 transcription factor-dependent induction of the epithelial-to-mesenchymal transition.