Overlapping of differential gene expression patterns from wild-type and ras knockout fibroblasts after serum stimulation for 1 hour or 8 hours. (a) Venn diagrams showing number of probesets contained in the intersections among the different lists of differentially expressed genes occurring simultaneously in WT, H-ras-/-, N-ras-/- or H-ras-/-/N-ras-/-fibroblasts after incubation of serum-starved cells in the presence of serum for 1 hour or 8 hours. (b) Venn diagrams showing overlapping among the lists of differentially expressed genes of H-ras-/-, N-ras-/- or H-ras-/-/N-ras-/- fibroblasts generated after excluding from them those loci showing similar values of differential expression (ratio of the R-fold values within the range 0.6 to 1.5) in the corresponding 1-hour or 8-hour WT controls.
Castellano et al. Genome Biology 2009 10:R123 doi:10.1186/gb-2009-10-11-r123