Enhanced apoptosis in N-ras-/- and H-ras-/-/N-ras-/- fibroblast cultures. Representative phase-contrast microscopic images of WT and ras knockout fibroblast cultures that were serum-starved, or stimulated with serum for 1 hour or 8 hours, as indicated. Flow cytometric analyses of corresponding preconfluent cultures of the same control and knockout cell lines are also presented. Graphics are representative of three separate determinations with similar results. The averaged percentage of apoptotic cells is included in each case.
Castellano et al. Genome Biology 2009 10:R123 doi:10.1186/gb-2009-10-11-r123