Conservation of hexamer submotifs of the yeast ACS DNA replication origin motif. Of the 24 hexamers, 21 are consistent with the ACS consensus TKTTTATRTTTWGTT and have positive z-scores in comparisons of S. cerevisiae and S. bayanus coding sequences. These results support the hypothesis that ACS motifs in coding regions are functionally active, and also indicate that COMIT is capable of detecting coding motifs functional at the DNA level.
Kural et al. Genome Biology 2009 10:R133 doi:10.1186/gb-2009-10-11-r133