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Structural and functional map of a bacterial nucleoid

Agustino Martínez-Antonio1*, Alejandra Medina-Rivera2 and Julio Collado-Vides2*

Author Affiliations

1 Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Irapuato, 36500, México

2 Programa de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México

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Genome Biology 2009, 10:247  doi:10.1186/gb-2009-10-12-247

Published: 11 December 2009

Abstract

Genome-wide mapping of transcription factor-DNA interactions in bacterial chromosomes in vivo has begun to reveal global zones occupied by these factors that serve two purposes: compacting the bacterial DNA and influencing global programs of gene transcription.