Research
Tandem repeats modify the structure of human genes hosted in segmental duplications
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* Corresponding author: Francesca D Ciccarelli francesca.ciccarelli@ifom-ieo-campus.it
Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello, 20139 Milan, Italy
Genome Biology 2009, 10:R137 doi:10.1186/gb-2009-10-12-r137
Published: 2 December 2009Additional files
Additional file 1:
For each group of paralogs, the genomic coordinates of exons, loci and repeats are reported, together with the transcriptional support.
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Additional file 2:
Table S1: features of variable ITRs associated with modifications of the gene structure. Table S2: effect of variable ITRs on coding sequences. Table S3: effect of variable ITRs on introns. Figure S1: number of paralogs associated with intron and exon modifications.
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Additional file 3:
For each over-represented category of the three main Gene Ontology classes (biological process, molecular function, and cellular component), the number and percentage of genes with variable ITRs and other genes in SDs are reported.
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