Genome Biology

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Non-imprinted allele-specific DNA methylation on human autosomes

Yingying Zhang1, Christian Rohde1, Richard Reinhardt2, Claudia Voelcker-Rehage3 and Albert Jeltsch1*

Author Affiliations

1 School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany

2 Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, D-14195 Berlin-Dahlem, Germany

3 Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany

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Genome Biology 2009, 10:R138 doi:10.1186/gb-2009-10-12-r138

Published: 3 December 2009

Additional files

Additional data file 1:

Amplicons analyzed and the correlated genes, genomic positions and primers used for bisulfite genomic sequencing and gene expression analysis.

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Additional data file 2:

Detailed information for all individuals selected for the analysis.

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Additional data file 3:

Confirmation of the bisulfite genomic sequencing results.

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Additional data file 4:

DNA methylation patterns of amplicons 23_1 and 23_2 in different individuals.

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Additional data file 5:

DNA methylation patterns of amplicon 262 in different individuals.

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Additional data file 6:

Methylation levels of homozygous individuals compared with the allelic methylation levels of heterozygous individuals for amplicons 23_1, 23_2 and 262.

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Additional data file 7:

Methylation patterns of amplicon 232 in different individuals.

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Additional data file 8:

ASM of amplicons 176_1 and 176_2.

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Additional data file 9:

Methylation levels of regions with ASM in HEK293 cells, HEPG2 cells and human fibroblasts from [12].

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Additional data file 10:

Allele-specific transcription factor binding sites predicted at the ASM amplicons and mechanism of ASM.

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Open Data