Overview of CSDeconv. After an initial stage in which enriched regions are identified and probability density functions associated with ChIP and control read locations are derived, we obtain enrichment profiles that describe the enrichment level throughout each enriched site for both forward and reverse reads. From the enrichment profiles, an initial estimate is made of the shape of an enrichment peak. The peak shape is used to deconvolve the enrichment profiles, deriving binding-site locations and magnitudes, which are then used to reestimate the peak shape, and this iterative cycle is repeated until convergence.
Lun et al. Genome Biology 2009 10:R142 doi:10.1186/gb-2009-10-12-r142