Protein function annotation by homology-based inference
1 Department of Biological Chemistry, The Hebrew University of Jerusalem, Sudarsky Center, Jerusalem 91904, Israel
2 Department of Biochemical Sciences, University of Rome "La Sapienza", Rome 00185, Italy
3 Research Department of Structural and Molecular Biology, University College, London WC1E, UK
4 European Bioinformatics Institute, Hinxton CB10 1SD, UK
5 Technische Universität, Munich, Germany
6 Helmholtz Zentrum, German Research Center for Environmental Health, Munich 85764, Germany
7 Pasteur Institute-Cenci Bolognetti Foundation, University of Rome "La Sapienza", Rome 00185, Italy
Genome Biology 2009, 10:207 doi:10.1186/gb-2009-10-2-207
Published: 2 February 2009Abstract
With many genomes now sequenced, computational annotation methods to characterize genes and proteins from their sequence are increasingly important. The BioSapiens Network has developed tools to address all stages of this process, and here we review progress in the automated prediction of protein function based on protein sequence and structure.
