Genome Biology

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The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus

Rachel Brower-Sinning1, Donald M Carter2, Corey J Crevar2, Elodie Ghedin3, Ted M Ross2,4 and Panayiotis V Benos1,5*

Author Affiliations

1 Department of Computational Biology, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA

2 Center for Vaccine Research, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA

3 Department of Medicine, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15261, USA

4 Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Lothrop Street, Pittsburgh, PA 15261, USA

5 Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Meyran Avenue, Pittsburgh, PA 15260, USA

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Genome Biology 2009, 10:R18 doi:10.1186/gb-2009-10-2-r18

Published: 12 February 2009

Additional files

Additional data file 1:

Plots of folding energies of vaccine strains WHO and CDC use against H5 influenza

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Open Data