Table 1 |
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|
List of top hits from computational analysis of mean cell area in images from a high-content genome-wide RNAi screen |
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|
Fly gene |
Human homologue |
Z-score |
Function |
|
|
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|
Sos |
SOS1 |
-4.09 |
Ras signaling |
|
drk |
GRB2 |
-3.73 |
Ras signaling |
|
CG11294 |
CART1 |
-3.07 |
Transcription factor |
|
gfzf |
GSTT1 |
-3.02 |
Glutathione transferase |
|
Pvr |
PDGF/VEGF |
-2.92 |
Receptor tyrosine kinase |
|
rl |
MAPK1 |
-2.80 |
Ras signaling |
|
Sec61alpha |
SEC61A2 |
-2.66 |
Protein secretion |
|
Rheb |
RHEB |
-2.52 |
Tor signaling |
|
Nup44A |
SEH1L |
-2.47 |
Nuclear pore |
|
Ras85D |
KRAS |
-2.30 |
Ras signaling |
|
csw |
PTPN11 (SHP-2) |
-2.22 |
Ras signaling |
|
CG9306 |
NDUFB9 |
-2.20 |
Mitochondrial electron transport |
|
CG9300 |
NOL11 |
-2.15 |
Sugar transporter |
|
fax |
C6orf168 |
-2.04 |
Axonogenesis |
|
Dsor1 |
MAP2K1 |
-2.02 |
Ras signaling |
|
|
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|
This list was derived from an initial hit list (Additional data file 1) following the confirmation of phenotypes by visual inspection and the exclusion of genes causing other cell shape phenotypes. Genes participating in the Ras signaling pathway are highlighted in bold. |
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|
Sims et al. Genome Biology 2009 10:R20 doi:10.1186/gb-2009-10-2-r20 |
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