Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

Neekesh V Dharia¹ , Amar Bir Singh Sidhu^2,3 , María Belén Cassera⁴ , Scott J Westenberger¹ , Selina ER Bopp¹ , Rich T Eastman² , David Plouffe⁵ , Serge Batalov⁵ , Daniel J Park⁶ , Sarah K Volkman^7,8 , Dyann F Wirth^6,7 , Yingyao Zhou⁵ , David A Fidock^2,9 and Elizabeth A Winzeler^1,5

¹  Department of Cell Biology, ICND 202, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA

²  Department of Microbiology, Columbia University College of Physicians and Surgeons, West 186th Street, New York, NY 10032, USA

³  The Broad Institute of MIT and Harvard, Cambridge Center, Cambridge, MA 02142, USA

⁴  Department of Biochemistry, Albert Einstein College of Medicine at Yeshiva University, Morris Park Avenue, Bronx, NY 10461, USA

⁵  Genomics Institute of the Novartis Research Foundation, John Jay Hopkins Drive, San Diego, CA 92121, USA

⁶  The Broad Institute of MIT and Harvard, Cambridge Center, Cambridge, MA 02142, USA

⁷  Department of Immunology and Infectious Diseases, Harvard School of Public Health, Huntington Avenue, Boston, MA 02115, USA

⁸  School for Health Studies, Simmons College, The Fenway, Boston, MA 02115, USA

⁹  Department of Medicine, Columbia University College of Physicians and Surgeons, West 186th Street, New York, NY 10032, USA