Table 4 |
|||
|
Summary of signaling modules |
|||
|
Number of rules |
Key component(s) |
Summary of key events |
|
|
|
|||
|
1 |
1 |
Pi3k, ErbB4 |
ErbB4 activation of Pi3k |
|
2 |
1 |
Snca |
Pyk2 activation of Snca |
|
3 |
1 |
Caml, Rsk |
Rsk activation of Caml |
|
4 |
1 |
Stat3 |
Stat3 activation by EgfR |
|
5 |
1 |
Irs, Pi3k |
Irs activation of Pi3k |
|
6 |
1 |
Rela |
Formation of Ikba, Nfkb1, Rela complex |
|
7 |
2 |
Pik3ca-mut |
Akt signaling through Pi3k mutant |
|
8 |
2 |
Mef2c |
Camk activation of Mef2c |
|
9 |
2 |
IL11R, Jak |
IL11R activation of Jak |
|
10 |
2 |
Elmo, Rac1 |
Elmo activation of Rac1 |
|
11 |
2 |
Abi1, Pir121 |
Wave1 activation dependent on Abi1 and Pir121 |
|
12 |
3 |
Mylk |
Mylk activation of Mlc |
|
13 |
3 |
RhoB |
RhoB activation |
|
14 |
3 |
EsR1, Bcat |
EsR1 activation by Rsk; Bcat activation |
|
15 |
3 |
Fos |
Fos activation by Erk |
|
16 |
3 |
Bcat |
Activation and degradation of Bcat |
|
17 |
4 |
Cav1, UpaR |
Integrin/Cav1 activation of Shc; UpaR activation |
|
18 |
5 |
Pten, Kras, Pik3ca |
Mutation rules |
|
19 |
5 |
ErbB4 |
ErbB4 activation of ErbB2, Shc; Grb2 relocation |
|
20 |
6 |
PrlR |
PrlR signaling |
|
21 |
7 |
Irs1 |
Irs1 activation; Grb2 translocation |
|
22 |
8 |
Pi3k |
Eight ways to activate Pi3k |
|
23 |
12 |
RhoB |
RhoB activation of first-order effectors |
|
24 |
12 |
Cbl |
Cbl-related signaling, including Rap1a, Crk, Dock |
|
25 |
14 |
Src |
Src-related signaling, including Fak, Pax, Cas |
|
26 |
15 |
EgfR |
First-order EgfR interactions including ErbB2, Grb2, Cbl |
|
27 |
16 |
Efna1 |
EphA2/Efna1 signaling; Integrin deactivation by EphA2 |
|
28 |
27 |
ErbB3 |
ErbB3 activation by Nrg1 and ErbB2; ErbB3 activation of Shc |
|
29 |
32 |
EgfR, Src |
Src-dependent activation of EgfR; Cdc42 signaling; activation of Src effectors |
|
30 |
76 |
Src, Rac1-GTP |
Rac1 signaling; MAPK activation |
|
|
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|
Heiser et al. Genome Biology 2009 10:R31 doi:10.1186/gb-2009-10-3-r31 |
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