Table 3

Gene Ontology categories significantly enriched among motif-containing genes

Motif

GO category

Description

p-value

Adjusted p-value


GLYCB

GO:0016530

Metallochaperone activity

1.00E-05

0.0004

MICB

GO:0016530

Metallochaperone activity

1.00E-05

0.0004

NTBA

GO:0022414

Reproductive process

1.00E-06

0.0001

NTBA

GO:0016530

Metallochaperone activity

1.00E-05

0.0004

NTBB

GO:0002376

Immune system process

1.00E-06

0.0002

NTBB

GO:0009987

Cellular process

0.0005

0.0110

NTBB

GO:0009055

Electron carrier activity

0.0025

0.0371

NTBB

GO:0008152

Metabolic process

0.0026

0.0367

NTBB

GO:0030234

Enzyme regulator activity

0.0030

0.0400

RPA

GO:0045735

Nutrient reservoir activity

1.00E-06

0.0001

RPA

GO:0005840

Ribosome

1.45E-06

0.0001

RPA

GO:0005198

Structural molecule activity

3.65E-06

0.0002

RPA

GO:0006412

Translation

0.0001

0.0039

RPA

GO:0009987

Cellular process

0.0004

0.0096

RPA

GO-0043226

Organelle

0.0005

0.0110

RPA

GO-0032991

Macromolecular complex

0.0005

0.0107

RPA

GO:0051234

Establishment localization

0.0008

0.0148

RPA

GO:0051179

Localization

0.0008

0.0156

RPB

GO-0044421

Extracellular region part

1.00E-07

3.52E-05

RPB

GO:0022414

Reproductive process

1.00E-06

0.0001

RPB

GO:0016530

Metallochaperone activity

1.00E-05

0.0003

RPB

GO:0006412

Translation

0.0001

0.0020

RPB

GO:0005840

Ribosome

0.0003

0.0074

RPB

GO-0043226

Organelle

0.0010

0.0172

RPB

GO:0009987

Cellular process

0.0018

0.0285

RPB

GO:0005198

Structural molecule activity

0.0018

0.0282


Significantly enriched GO categories (adjusted p-value < 0.05) for motif-containing genes. The results are listed by each motif and ordered based on their Benjamini Hochberg adjusted p-value. A good correlation is observed between the functional pathways associated with the seed genes and the GO category that is over-represented in the corresponding motif-containing genome-wide gene sets in the case of motifs NTBB, RPA and RPB.

Mullapudi et al. Genome Biology 2009 10:R34   doi:10.1186/gb-2009-10-4-r34

Open Data