Table 2

Biological pathways that are significantly enriched with E/HGTs

Type

Functional category

Species group

Total enzymes

EGT

HGT


Map group

Lipid met

Ostreococcus

64

10 (2.0*)

3

Map group

Lipid met

Plasmodium

36

6 (3.2)

-

Map group

Lipid met

Toxoplasma

52

9 (3.7)

-

Map

Bsyn of steroids

Diatoms

22

7 (2.7)

-

Map

Bsyn of steroids

Ostreococcus

18

5 (3.5*)

-

Map

Bsyn of steroids

Theileria

7

2 (7.0*)

-

Map

Fatty acid bsyn

Toxoplasma

4

2 (10.7*)

-

Map

Fatty acid bsyn

Plasmodium

5

2 (7.8*)

-

Map

Fatty acid met

Trypanosoma

6

2 (10.1*)

-

Module

C5 isoprenoid bsyn, non-mevalonate

Diatoms

7

4 (4.3)

-

Module

C5 isoprenoid bsyn, non-mevalonate

Theileria

6

2 (8.6*)

-

Module

C5 isoprenoid bsyn, non-mevalonate

Plasmodium

7

2 (6.4*)

-

Module

Fatty acid bysn, elongation

Ostreococcus

3

2 (6.6*)

-

Module

Fatty acid bysn, elongation

Plasmodium

3

2 (15.0)

-

Module

Fatty acid bysn, elongation

Toxoplasma

3

2 (11.1)

-

Map group

Carbohydrate met

Cryptosporidium

65

8 (2.6)

2

Map group

Carbohydrate met

Phytophthora

195

22 (2.8)

5

Map group

Carbohydrate met

Plasmodium

82

10 (2.4)

2

Map group

Carbohydrate met

Theileria

61

6 (2.4*)

1

Map

Galactose met

Phytophthora

8

2 (6.3*)

1

Map

Glycolysis/Gluconeogenesis

Phytophthora

19

4 (5.3)

1

Map

Glycolysis/Gluconeogenesis

Plasmodium

13

3 (4.5*)

-

Map

Pentose phosphate pathway

Phytophthora

12

3 (6.3)

1

Map

Pyruvate met

Cryptosporidium

8

2 (5.3*)

-

Map

Pyruvate met

Plasmodium

13

3 (4.5*)

1

Map

Pentose and glucuronate interconversion

Leishmania

6

-

3 (8.2)

Map

Starch and sucrose met

Cryptosporidium

11

2

2 (7.7*)

Map

Starch and sucrose met

Phytophthora

22

5 (5.7)

1

Module

Glycolysis

Phytophthora

8

2 (7.0*)

-

Map group

Energy met

Ostreococcus

54

9 (2.1*)

2

Map

Carbon fixation

Cryptosporidium

8

2 (5.3*)

-

Map

Carbon fixation

Ostreococcus

19

5 (3.3*)

-

Map

Nitrogen met

Toxoplasma

11

-

2 (6.8*)

Map

Reductive carboxylate cycle

Leishmania

6

-

2 (5.5*)

Map group

Other AAs

Leishmania

32

-

5 (2.6*)

Map group

Other AAs

Phytophthora

54

1

4 (3.6*)

Map

Arginine and proline met

Ostreococcus

10

-

3 (5.3*)

Map

Glutamate met

Plasmodium

15

-

2 (6.6*)

Map

Glutathione met

Leishmania

10

-

3 (4.9*)

Map

Lysine bsyn

Toxoplasma

6

1

2 (12.5)

Map

Nicotinate and nicotinamide met

Leishmania

4

-

2 (8.2*)

Module

Chorismate bsyn, phosphoenolpyruvate + erythrose-4P = > chorismate

Diatoms

6

3 (3.8*)

-

Module

Histidine bysn, PRPP = > histidine

Ostreococcus

5

-

2 (7.1*)

Module

Lysine bsyn, aspartate = > lysine

Toxoplasma

5

1

2 (16.6)

Map group

Cofactor and vitamins

Diatoms

70

15 (1.8*)

2

Map group

Cofactor and vitamins

Leishmania

28

-

5 (2.9*)

Map group

Cofactor and vitamins

Ostreococcus

65

13 (2.5)

4

Map

Biotin met

Saccharomyces

4

-

2 (29.7)

Map

Porphyrin and chlorophyll met

Diatoms

20

12 (5.1)

-

Map

Porphyrin and chlorophyll met

Leishmania

4

-

2 (8.2*)

Map

Porphyrin and chlorophyll met

Ostreococcus

21

12 (7.1)

2

Map

Thiamine met

Diatoms

3

-

2 (22.4)

Module

Biotin bsyn, pimeloyl-CoA = > biotin

Saccharomyces

3

-

2 (31.4)

Module

Heme bsyn, glutamate = > protoheme/siroheme

Diatoms

10

6 (4.5)

-

Module

Heme bsyn, glutamate = > protoheme/siroheme

Leishmania

3

-

2 (10.3*)

Module

Heme bsyn, glutamate = > protoheme/siroheme

Ostreococcus

10

5 (4.9)

1

Map group

Glycan bsyn

Phytophthora

9

1

2 (10.9*)

Map

Lipopolysaccharide bsyn

Phytophthora

5

1

2 (19.6)

Map group

Xenobiotics biodegradation and met

Ostreococcus

15

-

3 (3.5*)

Map

Aminoacyl-tRNA bsyn

Diatoms

19

6 (2.7*)

1


Significant over-representation of E/HGTs in biological pathways is shown on the following levels: Map group, KEGG map group; Map, KEGG map; Module, KEGG module. 'Total enzymes' is the number of enzymes in the species group within the defined category; 'EGT' and 'HGT' are counts of the number of transferred enzymes in the category followed in parentheses by the over-representation statistic for E/HGTs in that category (the proportion of E/HGTs for the category divided by the proportion of E/HGTs over all categories). Only statistically significant over-representation is shown and is indicated by asterisks (95% level) and dagger symbols (99% level). Significantly enriched pathways are not listed if the pathways contained only one E/HGT. The pathways are grouped by the KEGG map group they belong to in the following order: 'lipid metabolism', 'carbohydrate metabolism', 'energy metabolism', 'amino acid metabolism' and 'metabolism of other amino acids', 'metabolism of cofactors and vitamins', 'glycan biosynthesis and metabolism', 'xenobiotic biodegradation and metabolism' and 'amino-tRNA biosynthesis'. Abbreviations used in the pathway names: AA, amino acids; bsyn, biosynthesis; met, metabolism.

Whitaker et al. Genome Biology 2009 10:R36   doi:10.1186/gb-2009-10-4-r36

Open Data