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Chromatin conformation signatures of cellular differentiation

James Fraser1, Mathieu Rousseau2, Solomon Shenker1, Maria A Ferraiuolo1, Yoshihide Hayashizaki3, Mathieu Blanchette2 and Josée Dostie1*

Author Affiliations

1 Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Promenade Sir-William-Osler, Montréal, H3G1Y6, Canada

2 McGill Centre for Bioinformatics, McGill University, 3775 University, Montréal, H3A 2B4, Canada

3 RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045, Japan

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Genome Biology 2009, 10:R37  doi:10.1186/gb-2009-10-4-r37

Published: 19 April 2009

Abstract

One of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the regulation of gene expression. Here, we developed a suite of computer programs to identify chromatin conformation signatures with 5C technology http://Dostielab.biochem.mcgill.ca webcite. We identified dynamic HoxA cluster chromatin conformation signatures associated with cellular differentiation. Genome-wide chromatin conformation signature identification might uniquely identify disease-associated states and represent an entirely novel class of human disease biomarkers.